Comparison of Clinical Efficiency of Photodynamic Therapy and Topical Corticosteroid in Treatment of Oral Lichen Planus

• Status: Completed
• Trial end date: 2021-05-22
• Target enrollment: 0
• Participant gender: All

Summary

Lichen planus is a chronic inflammatory dermatosis. It most often affects the skin and mucous membranes. Sometimes lesions may appear in the area of nails (estimated at 10% of patients) or genital organs and anus.

The most dangerous form of lichen planus is lichen that develops on the oral mucosa. It is believed to be the cause of the development of oral cancer.

The vast majority of people suffering from lichen planus - 90%, experience spontaneous resolution of symptoms within a maximum of two years from the moment of their onset.

In about half of the patients, the changes disappear within about 6 months. People who have a problem that their ailments do not want to go away on their own must take into account the fact that treating lichen is not the easiest one.

Treatment of lichen is mainly based on alleviating its symptoms and accelerating the resolution of symptoms. Topical ointments containing strong glucocorticosteroids are usually applied to skin lesions or we can use Photodynamic Therapy

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Wroclaw Medical University
• Treatments: Triamcinolone; Triamcinolone Acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide

Criteria

Inclusion Criteria:

• having a histological diagnosis of OLP

• non smoker

• without diabetes melitus

• without hepatitis

Exclusion Criteria:

• diabetes melitus

• hepatitis

• occurrence dysplasia in the histopathological specimen;

• use of lichenoid reaction inducing medications and presence of amalgam fillings nearby the lesions;

• interventions for OLP in the previous 12 weeks;

• pregnant or breastfeeding women;

• proved or suspected hypersensitivity to any of the chemicals used in the treatment