Comparison of Combination Therapy: Montelukast and Inhaled Steroid on Exercise Induced Bronchoconstriction
Status:
Completed
Trial end date:
2009-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare the effects of 2 weeks therapy of montelukast,
budesonide, their combination on exercise induced bronchoconstriction (EIB) and airway
inflammation in children and young adults, not on regular controller therapy.
Inhaled corticosteroids (ICS) are potent anti-inflammatory agents, which are effective in
controlling and improving all aspects of asthma including the attenuation of EIB. However,
the effect of ICS monotherapy on EIB is comparable if not inferior to the effect of CysLTs
modifiers alone. This may be due to the lack of effect of ICS on the CysLT pathway. As a
consequence, the investigators hypothesize that the combination of ICS and CysLT modifiers
will offer a greater protection against EIB than either therapy alone. The different classes
of drugs may act on complementary pathways believed to be important in the pathophysiology of
EIB.