Comparison of Continuous and Pulsatile Apomorphine in Parkinson's Disease

• Status: Withdrawn
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the effects of apomorphine, given by two different methods, to determine how best to manage dyskinesias.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Oregon Health and Science University
• Collaborator: National Institute of Neurological Disorders and Stroke (NINDS)
• Treatments: Apomorphine

Criteria

Inclusion Criteria:

• idiopathic Parkinson's Disease

• clear response to levodopa (sinemet)

• "off" at least 20% of waking day

• dyskinesias present for at least two hours of waking day

• subject or caregiver able to master use of drug delivery system (injector pen or pump)

Exclusion Criteria:

• physical complications that would preclude safe participation

• standing systolic BP of <80

• lack of tolerance or response to apomorphine

• drug/alcohol abuse