Comparison of Different TRansesophageal Echocardiography Guided thrOmbolytic Regimens for prosthetIc vAlve Thrombosis
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
Despite high mortality and morbidity, the best treatment strategies for prosthetic valve
thrombosis (PVT) have been controversial. In this study the investigators wanted to identify
the most effective and safe regimen among different thrombolytic strategies.Transesophageal
echocardiography (TEE) guided thrombolytic treatment was administered to 182 consecutive
patients with PVT in 220 different episodes (156 women, mean age 43.2±13.06 years) between
1993 and 2009. These regimens included rapid streptokinase (Group I, 16 episodes), slow
streptokinase (Group II, 41 episodes), high dose (100 mg) tissue plasminogen activator (t-PA)
(Group III, 12 episodes), half-dose (50 mg) slow infusion (6-hours) of t-PA without bolus
(Group IV, 27 episodes), and low dose (25 mg) and slow infusion (6-hours) of t-PA without
bolus (Group V, 124 episodes). The study endpoints were thrombolytic success and in-hospital
mortality and non-fatal complication rates.
Phase:
N/A
Details
Lead Sponsor:
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital