Chronic post mastectomy pain syndrome (PMPS) is a chronic post-surgical neuropathic pain
following breast cancer surgeries and lasting more than three months after surgeries.
Pregabalin is originally used as an antiepileptic drug and identiļ¬ed as treatment for
neuropathic pain .There are several recent reviews have revealed that it reduces
post-operative opioid consumption and improves pain scores after breast surgeries. Duloxetine
is a serotonin and norepinephrine reuptake inhibitor. Its mechanism of action is related to
the potentiation of serotonergic and noradrenergic activity in the descending inhibitory pain
pathways of the central nervous system and used for treatment of neuropathic pain conditions
as painful diabetic neuropathy, neuropathic pain of lung cancer and chemotherapy induced
sensory neuropathy