Comparison of Effect of cARvedilol Compared To bISoprolol on cenTral Pulse Pressure in Hypertension (ARTIST) Study

• Status: Unknown status
• Trial end date: 2013-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare of carvedilol, a vasodilating beta-blocker and bisoprolol, a beta1- selective beta-blocker for reducing the central pulse pressure and thereby left ventricular (LV) mass in never-treated hypertensive patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yoshio Matsui
• Treatments: Bisoprolol; Carvedilol

Criteria

Inclusion Criteria:

• Never-treated hypertensive subjects, aged 20-80 years (at the time of informed consent), regardless of sex

• Clinic systolic BP/diastolic BP > 140/90 mmHg in a sitting position.

Exclusion Criteria:

• Beta-blocker contraindications(asthma, COPD…)

• Heart rate less than 55 bpm

• Subjects treated with nitrates

• Grade 3 hypertension (≥180 and/or ≥110 mmHg)

• Secondary hypertension or malignant hypertension

• History of heart failure, coronary artery disease, and stroke

• Arrhythmia

• Renal dysfunction (serum creatinine ≥2.0 mg/dl)

• Hepatic dysfunction (AST and/or ALT ≥100 IU/l)

• A history of or a suspected malignant tumor within 5 years of enrollment

• Chronic inflammatory disease

• Pregnancy, childbearing potential with inadequate contraception, breast feeding

• Inability to give informed consent