Comparison of Efficacy of Intra-articular Morphine vs Methylprednisolone in Patients With Knee Osteoarthritis.

• Status: Withdrawn
• Trial end date: 2018-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Prospective randomized double-blind controlled study. Participating patients with knee pain secondary to knee osteoarthritis will be randomized to either the DepoMedrol 40mg + 0.25% Bupivacaine (total Volume 5 ml) vs Morphine 3mg group+0.5% Bupivacaine (total volume 5ml) for their intra-articular knee injection. Before the injections, baseline values of NRS (Numerical rating scale) and WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) Questionnaire will be recorded by investigator. After the injections NRS and WOMAC will be recorded at 30mins and on discharge. Patient will be contacted by phone to assess the effectivity of block or any side effects on day 1, 7,30 and 45, information including NRS (at rest and household activity), WOMAC, supplemental analgesic, Side effects (pruritus, paresthesia, urinary retention, nausea, vomiting, dizziness, rash) will be obtained from the patient at the above time intervals. follow up visit will be scheduled 60days after the procedure for re-evaluation.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Henry Ford Health System
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

Age ≥ 18 years, patients undergoing intra-articular knee injection for unilateral or bilateral chronic knee pain due to knee osteoarthritis with symptoms (pain, functional limitation due to knee pain and restricted knee range of motion) for a period of at least 3 months in patient who already tried conservative management ( Physical therapy and medication management including NSAIDS if there is no contraindication).

Exclusion Criteria:

We will exclude patients with severe cardiopulmonary or brain disease; active infection; a history of anaphylactic reaction to contrast medium, anesthetic, opioids or steroids; pregnancy; malignant disease, patients who had under gone knee or hip surgery and patients who had been using opioids during the 24 hours prior to the study, patient refusal, uncontrolled diabetes with complications- BS > 300 and patient with ongoing anticoagulation therapy. Patient with osteoarthritis involving joints other than knee causing pain and functional limitation will also be excluded from study