Comparison of Efficacy of Metoclopramide , Promethazine and Prochloroperazine in the Treatment of Vertigo.

• Status: Recruiting
• Trial end date: 2023-08-30
• Target enrollment: 0
• Participant gender: All

Summary

Background: Vertigo as acute symptom seem to be one of most common presentation in ED, can be treated in ED with multiple medication . Objective: This study aimed to compare the therapeutic efficacy of metoclopramide, promethazine and prochloroperazine in patients presenting with signs and symptoms suggestive of acute peripheral vertigo to the ED . Methods: A 3-arm multi-center, randomized, double-blind, controlled study comparing three treatments for acute vertigo in three medical centers : AlNahdha hospital , Sohar Hospital and AFH hospital. Oman From February 2022 to February 2023.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Oman Medical Speciality Board
• Treatments: Diphenhydramine; Metoclopramide; Promethazine

Criteria

Inclusion Criteria:

• □ Acute peripheral vertigo with nausea or vomiting (vas, visual analog scale >5) during their emergency department episode of care for which the attending physician recommending antiemetic, onset with in 3 days .

• Age( 18- 60).

Exclusion Criteria:

• • Age >60.

• Any organic brain disease (Clear central cause; "malignancy with brain metastasis".)

• History of epilepsy

• Pregnancy.

• Dementia, Parkinson's disease

• Abnormal vital signs

• Any known drug allergy to the study drugs

• Undergoing chemotherapy or radiotherapy

• Mechanical bowel obstruction or perforation, gastrointestinal bleeding

• Inability to understand study explanation or outcome measures (any reason)

• Patients who refused to participate study.