Comparison of Esketamine-Propofol and Fentanyl-Propofol

• Status: Recruiting
• Trial end date: 2023-07-31
• Target enrollment: 0
• Participant gender: All

Summary

Propofol is widely used as an induction agent during general anesthesia. The prevalent induction dose may be associated with unacceptable cardiovascular instability, especially in elderly patients.The combination of ketamine and propofol has been shown to balance the cardiodepressant effects. Esketamine is dextrorotatory structure of ketamine but with stronger analgesic effects and fewer adverse events.However, there have been no previous published reports on the use of esketamine combined with propofol during induction. The main aim of this study was to investigate the haemodynamic effects of esketamine with propofol for the elderly during induction with LMA( laryngeal mask airway) insertion.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eye & ENT Hospital of Fudan University
• Treatments: Esketamine; Ketamine; Propofol

Criteria

Inclusion Criteria:

• age 》60 years

• American Society of Anesthesiologists (ASA) class I or II

Exclusion Criteria:

• contraindications to esketamine, such as glaucoma and large vascular aneurysms

• poorly controlled or untreated hypertension (systolic/diastolic blood pressure over 180/100 mmHg at rest)

• severe cardiopulmonary

• mental illness.

• LMA insertion failed.