Comparison of Extubation Delay After Prolonged Sedation
Status:
Recruiting
Trial end date:
2023-03-31
Target enrollment:
Participant gender:
Summary
This monocentric, prospective, controlled, randomized, single-blind study will be conducted
in surgical resuscitation at the Rouen University Hospital. The aim of our research project
is to evaluate the extubation time after sedation with inhaled isoflurane compared to
conventional intravenous sedation with midazolam, in patients who require prolonged sedation
(3 to 28 days) in a context of septic shock. This population is particularly at risk of
hypnotic accumulation due to the prolonged duration of use and the increased risk of
developing renal or hepatic impairment in connection with septic shock.
Based on data from the literature on shorter durations of up to 96 hours of sedation, the
investigators expect a decrease in the time to extubation in patients sedated with isoflurane
as well as a better quality of awakening with a decrease in resuscitation delirium. This
shortened duration of mechanical ventilation could have beneficial effects on the morbidity
associated with prolonged sedation and ventilation: reduction of pneumopathies acquired under
mechanical ventilation, reduction of the length of stay in resuscitation and hospitalization.