Comparison of Five Treatments in Patients With Plantar Warts

• Status: Terminated
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The principal objective of the study is to compare 5 usual strategies in the management of plantar warts which did not cure after 5 weeks of a salicylate ointment given just prior the trial. The trial will include immunocompetent patients coming from the community and should help the office-based dermatologists and hospital in the decision-making therapeutic process.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Collaborator: Society of Dermatology and venerology
• Treatments: Fluorouracil; Imiquimod; Salicylates; Salicylic Acid

Criteria

Inclusion Criteria:

• Male or female patient aged 18 years or more.

• Clinical evaluation

• Number of warts lower than 10 on the 2 feet and total diameter of warts lower than 10 cm, whether previously treated or not

• In treated patients, all potentially active treatment on warts since at least one month should be stopped.

• Effective contraception for women of childbearing age

• Immunocompetent patients

• Patient with one or more warts on soles and board feet.

• MYRMECIE : rounded warts, deep, covered with a stratum corneum more or less thick; after stripping, appear black points, very specific; often painful to pressure. They are lonely, single or not. They could regroup galley thick. The stripping can them to individualize.

• Mosaic : plate small warts, superficial, often sitting on the heel or Forefoot. Little painful, they are often ignored by the patients when they appear

• Patient affiliated to the French social security.

Exclusion Criteria:

• Patient suspected to be immunocompromised

• Patient aged under 18 years

• Patient refusing to sign the consent

• Pregnant or lactating women

• Plantar calluses

• Known hypersensitivity to imiquimod (Aldara®) or any excipients of the cream (isostearic acid, benzyl alcohol, cetyl alcohol, stearyl alcohol, paraffin, polysorbate 60, sorbitan stearate, glycerol, methyl hydroxybenzoate, propyl hydroxybenzoate, xanthan gum, purified water)

• Known hypersensitivity to 5 fluoro-uracil (Efudix®) or any excipients of gel (stearyl alcohol, Vaseline, polysorbate 60, propyleneglycol, purified water - conservatives: METHYL PARAHYDROXYBENZOATE, PROPYL PARAHYDROXYBENZOATE)

• Contra-indication to Pomade M.O Cochon® (Known allergy to any components)

• Known hypersensitivity to Blenderm®

• Extra plantar concomitant warts (to exclude risk of endogenous recontamination by an extra plantar site)

• Plantar hyperhidrosis making impossible adhesion of plaster.