Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare two preoperative chemotherapy regimens based on high-dose methotrexate courses given alternately either with doxorubicin or with etoposide-ifosfamide.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Gustave Roussy, Cancer Campus, Grand Paris
• Treatments: Doxorubicin; Etoposide; Etoposide phosphate; Ifosfamide; Isophosphamide mustard; Liposomal doxorubicin; Methotrexate

Criteria

Inclusion Criteria:

• non metastatic limb osteosarcoma,

• age less than 20 years,

• biopsy proven high-grade osteosarcoma,

• no previous treatment,

• no contraindication to chemotherapy

• no previous malignancy,

• Written informed consent.

Exclusion Criteria:

• juxta-cortical sarcoma and microcellular anaplastic sarcoma,

• previous anticancer treatment

• contraindication to chemotherapy

• previous malignancy,