Comparison of Hypertonic Saline and Mannitol on Brain Relaxation During Supratentorial Tumors Resection

• Status: Not yet recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Hyperosmotic agents are used to decrease intracranial pressure. The aim of the study is to compare the effects of continuous 3% hypertonic saline (HS), bolus HS and 20% mannitol on intraoperative brain relaxation in patients with raised intracranial pressure during surgery for supratentorial tumors.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Istanbul University
• Treatments: Mannitol

Criteria

Inclusion Criteria:

• Elective supratentorial tumor resection

• Glioblastoma multiforme

• Metastatic tumor

• Intracranial shift >0.5 cm

• GCS>13

Exclusion Criteria:

• Renal failure

• Heart failure

• Electrolyte imbalance