Comparison of Intralesional Tranexamic Acid and Platelets Rich Plasma in the Treatment of Melasma
Status:
Completed
Trial end date:
2023-04-30
Target enrollment:
Participant gender:
Summary
ABSTRACT Objective: To study the efficacy while comparing Intralesional tranexamic acid Vs
Platelets rich plasma (PRP) in treatment of Melasma.
Study design: Randomized-controlled trial (RCT). Study setting and duration: Dept of
dermatology, CMH-Abbottabad, Nov-2022 /April-2023.
Methodology: The sample size of 60 patients 20 to 40 years were calculated by using Openepi
App. The informed consent was taken. The patients were randomly allocated to two groups:
Group A (30 patients injected with Intradermal Tranexamic acid (4mg/ml) and Group B (30
patients treated with PRP (1ml) intra-dermally, every fourth week for up to 12 weeks between
both groups). The mMASI scale was used to evaluate all patients. The final evaluation was
performed on the 24th week of follow-up. For analysis Statistical Package for the social
sciences version-27 was used. To determine statistical significance a paired t-samples test
with a p-value of < 0.05 was applied.