Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction

• Status: Completed
• Trial end date: 2019-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Post-operative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon. Most patients will receive general anesthesia during surgery. Two groups of general anesthetics are used for this purpose. We hypothesize that the incidence of POCD is not different in patients received intravenous anesthetics only or sevoflurane (a volatile anesthetic-based general anesthesia) for their major intra-abdominal surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Sun Yat-sen University
• Collaborators: Baxter (China) Investment Co. Ltd.; First Affiliated Hospital, Sun Yat-Sen University; First People's Hospital of Foshan; Guangdong Provincial People's Hospital; Guangdong Provincial People's Hospital, China; Huaqiao Hospital in Guangzhou, China; Nanfang Hospital of Southern Medical University; Nanfang Hosptial, China; Third Affiliated Hospital, Sun Yat-Sen University
• Treatments: Propofol; Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

1. major elective gastrointestinal, gynecological, prostate or bladder surgery patients who are ≥ 60 years old.

2. the surgery is laparoscopic surgery and is expected to last for ≥ 2 hours under general anesthesia and the patient will stay in hospital for at least 7 days after surgery.

3. lack of serious hearing and vision impairment and be able to read so that neurobehavioral tests can be performed.

Exclusion Criteria:

1. Patients are not expected to be alive for longer than 3 months.

2. Mini-mental State Examination (MMSE) [18] score ≤ 23.

3. history of dementia, psychiatric illness or any diseases of central nervous system.

4. current use of sedatives or antidepressant.

5. alcoholism and drug dependence.

6. patients previously included in this study (for patients who have second intra-abdominal surgery during the study period).

7. difficult to follow up or patients with poor compliance.

8. uncontrolled hypertension (> 180/100 mmHg)