Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis

• Status: Completed
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether oral cephalexin is equivalent to intravenous cefazolin plus oral probenecid for the treatment of uncomplicated skin and soft tissue infections in patients that present to the emergency department.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kelowna General Hospital
• Collaborators: Canadian Society of Hospital Pharmacists; Capital Health, Canada; Interior Health Authority, Canada
• Treatments: Cefazolin; Cephalexin; Probenecid

Criteria

Inclusion Criteria:

• Patients presenting to the emergency department with a presumed diagnosis of mild to moderate skin and soft tissue infection

• Deemed well enough to be treated as an outpatient

• 19 years of age or older

Exclusion Criteria:

• known allergy to study drugs

• known chronic kidney disease with a creatinine clearance <30 mL/min

• known previous methicillin-resistant staphylococcus aureus (MRSA) infection

• use of antibiotics for greater than 24 hours in the past 7 days

• wound/abscess requiring operative debridement or incision and drainage

• suspected necrotizing fasciitis, osteomyelitis or septic arthritis

• febrile neutropenia

• concomitant documented bacteremia

• Two or more signs of systemic sepsis

• new altered mental status

• infections at a site involving prosthetic materials

• animal or human bite wound infections

• post-operative wound infections

• known peripheral vascular disease

• superficial thrombophlebitis

• pregnant/breastfeeding

• obesity (BMI > 30 kg/m2)