Comparison of Loading Dose Magnesium Sulphate With Prichard Regimen in the Management of Severe Preeclampsia and Eclampsia.

• Status: Completed
• Trial end date: 2023-06-30
• Target enrollment: 0
• Participant gender: Female

Summary

Preeclampsia/eclampsia is part of a spectrum of multi-systemic pregnancy disorder that contributes substantially to maternal and perinatal morbidity and mortality, especially in low resource setting. This study was done in Abakaliki, Ebonyi State, Southeast Nigeria.

To compare the efficacy of loading dose of magnesium sulphate with that of the Pritchard regimen in the prevention of eclampsia in severe preeclampsia and recurrent fits in eclampsia in a low resource setting.

A prospective, single blinded randomized controlled study of loading dose versus Pritchard regimens of MgSO4 at the Teaching Hospital Abakaliki. One hundred and twenty patients were recruited 60 to each arm using computer-generated numbers. Sociodemographic characteristics, efficacy and adverse effects of the drug on the mother and baby were noted.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federal Teaching Hospital Abakaliki
• Treatments: Magnesium Sulfate

Criteria

Inclusion Criteria:

• Pregnant women with severe preeclampsia

• Pregnant women with eclampsia

• Signing of informed consented to participate in the study.

Exclusion Criteria:

• Refusal of consent,

• Gestational age < 28 weeks

• Received magnesium sulphate prior to presentation

• mild preeclampsia

• chronic hypertension in pregnancy

• Medical or Obstetrical complication of pregnancy.