Comparison of MgSO4 Versus Meperidine for Prevention of Shivering During Spinal Anesthesia

• Status: Completed
• Trial end date: 2021-06-30
• Target enrollment: 0
• Participant gender: All

Summary

This was a double-blind randomized interventional study of 100 patients divided into two groups. Group M received MgSO4 30 mg/kg, and group P received meperidine 0.5 mg/kg intravenously in 100 ml of 0.9% NaCl before undergoing spinal anesthesia. Participants were non-pregnant patients between 18-65 years of age, belonging to the American Society of Anesthesiologist physical status I or II. Shivering was regarded as significant if it occurred at grade 3 or 4. Data of patient characteristics, shivering degree, tympanic membrane temperature, vital sign, and side effects were recorded.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: AnestesiaR
• Treatments: Magnesium Sulfate; Meperidine

Criteria

Inclusion Criteria:

• Aged 18-65 years old

• American Society of Anesthesiologist (ASA) physical status I or II

• Planning for spinal anesthesia

Exclusion Criteria:

• History of allergy to the drugs used in the study

• Pregnant patients

• With neuromuscular disease, hyperthyroid, severe cardiopulmonary diseases, liver and/or renal disorders

• Used drugs that could interact with MgSO4 such as nifedipine

• Preoperative body temperature less than 36oC or more than 37.5oC