Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis

• Status: Completed
• Trial end date: 2010-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess the clinical and microbiological effectiveness of the moxifloxacin compared with the combination ciprofloxacin - metronidazole, when used as adjunctive therapy to scaling and root planning for the treatment of advanced chronic periodontitis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Facultad Nacional de Salud Publica
• Collaborator: Universidad de Antioquia
• Treatments: Ciprofloxacin; Fluoroquinolones; Metronidazole; Moxifloxacin; Norgestimate, ethinyl estradiol drug combination

Criteria

Inclusion Criteria:

• 18 years of age and up

• clinical and radiographic signs of severe (CAL 5 mm or more) chronic periodontitis.

• at least 20 natural teeth in situ

• pocket probing depths (PPDs) of ≥ 5 mm at a minimum of eight tooth sites

• willingness to participate and to be available at all times required for participation

• over 30% of the teeth present must have a PPDs)≥ 4 mm and insertion loss ≥ 5 mm evaluated by an experienced periodontist

• informed consent signed by the patient

Exclusion Criteria:

• if they (or parents or siblings) show confirmed or assumed allergies or hyper-sensitive skin reactions against moxifloxacin, ciprofloxacin (or other quinolones as listed in the "summary of product characteristics, Version Juli 2005"), metronidazole (or other 5-nitroimidazoles and ingredients of Flagyl® 400mg as listed in the "summary of product characteristics, Version Juli 2007"), systemic diseases or conditions as listed in the above mentioned "summary of product characteristics"

• subjects who have undergone antibiotic therapy three months before the start of the study under interrogation

• have Down's syndrome

• known AIDS/HIV

• regularly take systemic medication affecting the periodontal conditions, e.g. phenytoin, nifedipine, and/or steroid drugs

• professional periodontal therapy during 6 months prior to baseline

• require antibiotic treatment for dental appointments

• are pregnant or breastfeeding