Comparison of Multiple-, Single- and Zero-dose of Ciprofloxacin Prophylaxis in Retrograde Intrarenal Surgery

• Status: Unknown status
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the postoperative systemic inflammatory response syndrome (SIRS) rates undergoing retrograde intrarenal surgery (RIRS) after multiple-, single-, zero-dose of ceftriaxone prophylaxis in a prospective randomized trail.

The investigators will enroll 450 patients who are candidates for RIRS in the investigators study. By simple random sampling technique, patients will be assigned to three groups (multiple-, single-, zero-dose of ceftriaxone prophylaxis,respectively). In addition to the difference of usage of ciprofloxacin prophylaxis, the rest of the procedure is the same in all three groups.The end point of the study is the comparison of outcome of procedure including SIRS rate, stone free rate (SFR), operation time, length of stay,and hematuresis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guohua Zeng
• Treatments: Ciprofloxacin

Criteria

Inclusion Criteria

• Decision to performed RIRS to treat the kidney stones

• American society of Anesthesiology (ASA) score 1 and 2

• Kidney stones of diameter < 2.5 cm

Exclusion Criteria:

• Positive preoperative urine culture

• Pyruria (>10 white blood cells per high-power field)

• Antibiotics treatment of UTI in the last 4 weeks

• Immunocompromised

• Diabetes mellitus

• Allergy to quinolone

• Existing ureteric stents

• Turbid pelvic urine or purulent stone surface observed intraoperatively

• Ureteral stricture, renal or urethral deformity