Comparison of Nasal Saline Irrigation Bottle Contamination Between Two Solutions

• Status: Unknown status
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Rhinosinusitis is one of the most prevalent diseases within the United States and leads to decreased quality of life for patients suffering from this condition. A foundation in treatment for rhinosinusitis is nasal saline irrigations, which are administered through an irrigation bottle. The irrigation bottles are prone to contamination by bacterial and fungal species despite proper maintenance.

A new commercially available irrigation solution has been created using chitosan, a natural polysaccharide with antibacterial and antifungal properties. This research project will examine the ability of chitosan to decrease or prevent contamination of irrigation bottles after 1 month use by adult patients with rhinosinusitis.

Participants in this project will use either saline or chitosan irrigation solution for 1 month and then switch to the other solution for 1 month. Following 1 month of use, the irrigation bottles will be cultured to determine if chitosan irrigation solution decreased the contamination of the irrigation bottles.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Virginia
• Treatments: Chitosan; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• participants will be: 18 years old or older,

• diagnosed with rhinosinusitis based on history and physical examination performed for clinical care

• intervention to be prescribed would include nasal irrigation,

• able to understand and comply with the study protocol instructions, including the return the irrigation bottles

Exclusion Criteria:

• children less than 18 years old,

• unable to understand or perform the saline irrigations, or protocol instructions including the return the irrigations bottles after 1 month of use

• prisoners

• those with shellfish allergies