Comparison of Olanzapine and Metoclopramide For Treatment Of bReakThrough Emesis

• Status: Terminated
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This trial is designed to evaluate olanzapine compared to the metoclopramide in the treatment of break through emesis after prophylaxis with dexamethasone, 5-HT 3 receptor antagonists and aprepitant in patients receiving chemotherapy. Efficacy will be assessed using a modified MASCC questionaire with a visual analog scale.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Karin Jordan
• Treatments: Aprepitant; Dexamethasone; Metoclopramide; Olanzapine

Criteria

Inclusion Criteria:

• break through emesis after prophylaxis with dexamethasone, 5-HT 3 receptor antagonists and aprepitant in patients receiving chemotherapy defined as vomitus or nausea>25mm on VAS

• signed IC

Exclusion Criteria:

• psychiatric disorders

• drug abuse

• pregnancy

• high dose chemotherapy

• treatment with other antiemetic drugs