Comparison of Opioid and Duloxetine for Postoperative Pain Control After Total Knee Arthroplasty: RCT
Status:
Not yet recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) has recently been reported to be effective
in controlling pain in persistent chronic pain caused by joint surgery and arthritis.
However, opioids are important drugs that still play a pivotal role in pain control after
surgery. In this study, we want to investigate the difference of the result among patients
who undego total knee arthroplasty (TKA), of the result of pain control after TKA from SNRI
administration of duloxetine and opioid in two groups. We designed a randomized controlled
study (RCT) for the effect of post-TKA pain control to determine whether SNRI is effective in
controlling post-TKA pain compared to Opioid, and whether there is a difference in side
effects.