Comparison of Oral Paracetamol and Zolmitriptan Efficacy in the Treatment of Acute Migraine in Emergency Department

• Status: Completed
• Trial end date: 2017-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Migraine is a chronic and sometimes progressive disorder, characterized by headache, recurrent episodes, and other associated symptoms. Migraine is the most common cause of headache among patients who applied to emergency services.

The purpose of the investigators is to compare the efficacy of oral paracetamol and zolmitriptan in the treatment of acute migraine headache in an emergency department.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pamukkale University
• Treatments: Acetaminophen; Oxazolidinones; Zolmitriptan

Criteria

Inclusion Criteria:

• Patients were eligible for inclusion if they were aged 18 years or older, 65 years or younger

• Had acute migraine attack without aura

• VAS (visual analog scale) score >50 mm , NRS (Numeric Rating Scale) score >5

• Patients whose written consent is obtained by agreeing to participate in the study

Exclusion Criteria:

• Those who refuse to participate in the work

• Patients younger than 18 years or older than 65 years

• Those who use ergotamine derivative drugs in the last 24 hours

• Have received analgesics in the last 6 hours

• Patients with severe liver, kidney, lung and heart failure

• To have active peptic ulcer bleeding or perforation

• Have a history of upper gastrointestinal disease

• To be Pregnancy and breast-feeding

• Patients of childbearing age who are not using a birth control method.

• Allergy to medicines used in work

• Hemodynamically unstable patients

• Patients with renal transplantation

• Blood pressure uncontrolled hypertension patients

• Patients with cerebrovascular disease history

• Patients with ischemic heart disease or coronary spasm / printzmetal angina

• Patients with arrhythmia accompanying Wolff-Parkinson-White syndrome or accessory conduits in the heart

• Patients with Glucose 6 Phosphate Dehydrogenase (G6PD) deficiency

• Those with other systemic diseases,

• Patients with a Visual Analogue Scale (VAS) pain score less than 50 mm

• Illiterates and patients with vision problems