Comparison of Outcomes During MRI Sedation With Midazolam-dexmedetomidine Versus Ketamine-dexmedetomidine

• Status: Terminated
• Trial end date: 2018-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will compare 2 different sedation drugs (Ketamine and Midazolam) when they are used with another sedating medicine called Dexmedetomidine for MRI sedation. This study hopes to measure the impact each drug has on what happens during and after MRI sedation with Dexmedetomidine

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Louisville
• Treatments: Dexmedetomidine; Ketamine; Midazolam

Criteria

Inclusion Criteria:

1. Inpatient at Kosair Children's Hospital.

2. Order placed by treating team for MRI of the brain with sedation.

3. Age less than or equal to 18 years.

4. Plan to sedate with dexmedetomidine, regardless of study participation.

Exclusion Criteria:

1. Previous adverse reaction to dexmedetomidine or clonidine

2. Current use of clonidine as a routine medication

3. Concurrent use of a heart-rate decreasing medication (digoxin, propranolol)

4. Contraindication to ketamine use

• Intracranial hypertension or traumatic brain injury

• Intraocular hypertension of eye trauma

• Pulmonary hypertension requiring medical management

5. Planned additional procedure during the sedation encounter (non-brain MRI, lumbar puncture, EEG etc)