Comparison of Oxycodone to Control Moderate or Severe Oral Mucositis Pain Induced by Chemoradiotherapy
Status:
Unknown status
Trial end date:
2018-06-01
Target enrollment:
Participant gender:
Summary
Background:Although concurrent chemoradiotherapy is effective for improving disease-free
survival and overall survival in patients with locally advanced nasopharyngeal carcinoma.
However,the oral mucositis pain evoked by the chemoradiotherapy itself reduces food intake
and frequently halts the treatment. Thus, pain control is an important problem in
chemoradiotherapy for nasopharyngeal carcinoma.We performed to examine whether early
induction of low-dose, opioid from moderate pain reduced total dose of Oxycodone during
chemoradiotherapy, while improves the quality of life and reduce weight loss.
Objective:Present clinical trial to investigate the early introduction of opioids suppressed
the transient increase in the numeric rating scales(NRS) score for pain and compared with
conventional treatment.
Methodology:The subjects will recruit 70 patients who were hospitalized for nasopharyngeal
carcinoma. 70 patients were divided into two groups, depending on whether the pain was
moderate or severe when an opioid was introduced.Differences between groups were compared
using T test protected least significant difference for one-factor analysis of variance. All
statistical analyses were performed using SPSS(Statistic Package for Social Science)
software.P-values < 0.05 were considered statistically significant.