Comparison of Phenylephrine and Norepinephrine for Spinal-induced Hypotension
Status:
Completed
Trial end date:
2020-05-05
Target enrollment:
Participant gender:
Summary
Hypotension after spinal anaesthesia for cesarean deliveries is frequently encountered.
Phenylephrine an α-agonist is commonly used for the prevention and treatment of
spinal-induced hypotension. Phenylephrine causes baroreceptor-mediated bradycardia leading to
subsequent reduction in cardiac output. Preservation of heart rate and cardiac output is
important in high-risk conditions such as placental insufficiency, fetal distress and
maternal cardiac disease. Recently, norepinephrine has been found as effective as
phenylephrine in treatment of spinal induced hypotension. When norepinephrine is used as a
bolus, it is effective at maintaining blood pressure while also conferring a greater heart
rate and cardiac output compared to phenylephrine.
Phase:
Phase 3
Details
Lead Sponsor:
Tribhuvan University Teaching Hospital, Institute Of Medicine.