Comparison of Potassium Binders in the ER

• Status: Recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Compare efficacy of 3 oral potassium binders (cation exchange resins) on lowering blood potassium, in patients presenting to the Emergency Room with acute hyperkalemia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, Irvine
• Treatments: Polyethylene glycol 3350; Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

• Plasma potassium > 5.5 mEq/L

• Age ≥18 years

• Patient able to provide written informed consent

Exclusion Criteria:

• Recent bowel surgery

• Ileus or bowel obstruction

• Pseudohyperkalemia signs and symptoms, such as excessive fist clenching, hemolyzed blood specimen, severe leukocytosis or thrombocytosis

• Pregnancy

• Active psychiatric disorder

• Diabetic ketoacidosis or hyperkalemia caused by any condition for which a therapy directed against the underlying cause of hyperkalemia would be a better treatment option

• Dialysis session expected within 4 hours after randomization

• History of hypersensitivity to sodium polystyrene sulfonate resin or patiromer

• Concurrent use of sorbitol (due to increased risk of intestinal necrosis when used with sodium polystyrene sulfonate)