Comparison of Regimens MPIB, CIPCEA, PCEA

• Status: Active, not recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

Epidural analgesia is the gold standard of pain relief for labour pain. Despite this, more than 50% of parturients continue to experience pain leading to suffering and increased caregiver workload. Women who have increased pain tend to have lower successful patient bolus demands when patient controlled epidural analgesia (PCEA) is utilised and have dysfunctional labour requiring obstetric intervention such as Caesarean or instrumental delivery. Labour pain often escalates and worsens as labour progresses requiring an individualized, variable, flexible analgesic regimen. Bolus epidural administrations have been shown to improve uniform spread of local anaesthetics with better pain relief, compared to fixed background infusions.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: KK Women's and Children's Hospital
• Treatments: Anesthetics; Anesthetics, Local; Fentanyl; Ropivacaine

Criteria

Inclusion Criteria:

1. Healthy (ASA physical status 1 and 2) nulliparous parturients at term (≥36 weeks gestation);

2. Singleton foetus

3. Early labour (cervical dilation ≤5cm)

4. Request labour epidural analgesia

5. At least 21 years of age

Exclusion Criteria:

1. parturients with multiple pregnancies

2. non-cephalic foetal presentation

3. obstetric (e.g. pre-eclampsia, premature rupture of amniotic membranes, gestational diabetes on insulin) and uncontrolled medical (e.g. cardiac disease) complications

4. have contraindications to neuraxial blockade or have received parenteral opioids with the last 2 hours.