Comparison of Remimazolam With Flumazenil vs. Propofol During RFCA for Atrial Fibrillation

• Status: Not yet recruiting
• Trial end date: 2023-05-30
• Target enrollment: 0
• Participant gender: All

Summary

This prospective randomized trial aims to compare recovery time from discontinuation of remimazolam followed by flumazenil administration vs. propofol total intravenous anesthesia as the main general anesthetics during radiofrequency catheter ablation treatment of atrial fibrillation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Flumazenil; Propofol

Criteria

Inclusion Criteria:

• Adult patient, age 20-75 years, scheduled for radiofrequency catheter ablation of atrial fibrillation under general anesthesia

Exclusion Criteria:

• Patients who are not alert before procedure

• Hemodynamicaly unstable patients before procedure

• Patients with history of adverse reaction of allergic reaction to study drugs

• Patients who are anticipated to be unable to remove supraglottic airway or endotracheal tube due to severe dyspnea or need for mechanical ventilatory support

• Use of sedatives (anxiolytics, psychoactive medication, antidepressants, hypnotics) within 24 h

• Known galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption

• Severe hepatic or renal dysfunction

• Alcohol or drug dependence

• Organic brain disorder

• Spinal or cerebellar ataxia

• Acute narrow-angle glaucoma

• Patients with shock or coma

• Pregnant or lactating women

• Patients with hypersensitive to beans or peanut

• Patients who refuse to participate