Comparison of Salivary Interleukin-1β and Matrix Metalloproteinase-8 Levels in Individuals With Chronic Periodontitis

• Status: Unknown status
• Trial end date: 2018-04-11
• Target enrollment: 0
• Participant gender: All

Summary

Periodontitis is an infectious inflammatory disease affecting the periodontal tissue (Gingivae, alveolar bone, periodontal ligament and cementum). Chronic Periodontitis is considered to be the most prevalent disease after dental caries which is linked to increased levels of C- reactive protein, interleukins and matrix metallo-proteinases. Interleukin- 1β and Matrix metalloproteinase-8 have been shown to be robust markers of inflammatory cascade of chronic periodontitis.Various treatment modalities including scaling and root planing, toothpastes and chlorhexidine based mouthwashes have been are known to be associated with various side effects like teeth staining, altered taste sensation, mucosal burning. Hence,the use of natural medicaments could provide a better alternative because of their fewer side effects and cost effectiveness.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Health Sciences Lahore

Criteria

Inclusion Criteria:

• Male and female healthy individual

• Individuals diagnosed with chronic periodontitis according to the WHO criteria.

• Age 19 to 40 years.

Exclusion Criteria:

• Patients with gingivitis only.

• Patients using tobacco products and alcohol.

• Underlying systemic pathology such as diabetes mellitus, cardiovascular disease, arthritis etc.

• Oral mucosal pre-neoplastic lesions (leukoplakia, erthroplakia, lichen planus) and oral carcinomas.

• Obese patients.

• Pregnant females.

• Xerostomia.

• Previous history of radiotherapy or chemotherapy.

• Positive history of oral prophylactic procedures (mouthwashes and antibiotics).

• Positive history of any periodontal treatment during last 6 months.

• Positive antibiotic therapy history within last month of study.