Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy

• Status: Not yet recruiting
• Trial end date: 2022-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess the effectiveness of squat-to-stand maneuver in eliciting left ventricular outflow gradients in patients with Hypertrophic Cardiomyopathy (HCM) compared to Valsalva, amyl nitrite inhalation, and exercise stress echocardiogram (ESE).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Amyl Nitrite

Criteria

Inclusion Criteria:

• Adults ≥ 18 y/o referred for an outpatient echocardiogram.

• Clinical diagnosis of Hypertrophic Cardiomyopathy (HCM).

• Both amyl nitrite inhalation and squat-to-stand maneuver performed during echocardiogram.

Exclusion Criteria:

• Patients < 18 at the time of echocardiogram.

• Studies without documented provocative maneuvers.

• Patients with resting obstruction (MIG > 50 mmHg).

• Patients unable to undergo the squat-to-stand as protocolled based because of physical limitations.

• Patient with contraindications to amyl nitrite administration.