Overview

Comparison of Subconjunctival 5-Fluorouracil (FU) Injection and Mitomycin C for Treatment of Early Bleb Failure

Status:
Unknown status

Trial end date:
1969-12-31

Target enrollment:
0

Participant gender:
All

Summary

purpose : to evaluate and compare the effectiveness and complication of 5-FU injections and MMC drop in management of early bleb failure . Design:Randomized clinical trial Methods:Patients with low injected bleb in first month after filtering or combined surgery with MMC which don't respond to high frequent topical steroids and removal of releasable sutures will be randomize to either 5-FU injection or Mitomycin drop 0.02%.For each patient slit photograph in first day of recruiting,first two weeks and first and third month will be obtained.Patients will follow for at least 3 months and IOP ,bleb configuration will check as primary outcome measures.Preoperative and postoperative data,complications,and the need for further surgical procedures will be evaluated.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Shahid Beheshti University of Medical Sciences

Treatments:

Mitomycin
Mitomycins

Criteria

Inclusion Criteria:

- Patients with low,injected bleb in first month after trabeculectomy or combined
trabeculectomy&phaco which not respond to high frequent topical steroids or removal of
releasable sutures

Exclusion Criteria:

- Injected bleb due to complications of surgery such as button hole formation

- Injected bleb due to blebitis

- Bleb leakage

- Flat AC

- Pregnant or nursing mothers

- Injected bleb after bleb reconstruction