Comparison of Sufentanil, Fentanyl and Remifentanil in Combination With Midazolam During Bronchoscopy Under Conscious Sedation

• Status: Completed
• Trial end date: 2019-03-26
• Target enrollment: 0
• Participant gender: All

Summary

The best opioid for bronchoscopy is still unclear.This randomized double-blind prospective study was conducted on a total of 60 patients who were randomly allocated into 3 groups: Group S received sufentanil 0.1 mcg/kg, Group F received fentanyl 1 mcg/kg and Group R received remifentanil target-controlled infusion with effect-site target concentration of 1ng/ml. Patients in all groups received midazolam to achieve moderate levels of sedation as assessed by the Narcotrend (NT; between B1 and C2). Adverse events, patient tolerance and physician satisfaction were analized.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guangzhou Institute of Respiratory Disease
• Treatments: Fentanyl; Midazolam; Remifentanil; Sufentanil

Criteria

Inclusion Criteria:

• ASA grade I-II

Exclusion Criteria:

1. psychological disorders

2. SpO2<90% in ambient air

3. hypersensitivity or allergy to anaesthetic drugs or benzodiazepine

4. severe chronic obstructive pulmonary disease (forced expiratory volume in 1 s ,50% of predicted value, requirement for oxygen therapy)

5. unstable haemodynamic status

6. habitual alcohol consumption

7. asthmatic patients