Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is performed to compare the efficacy of terlipressin, somatostatin, and octreotide in patients with variceal bleeding for the control of variceal bleeding in combination with endoscopic therapy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Korea University
• Treatments: Lypressin; Octreotide; Somatostatin; Terlipressin

Criteria

Inclusion Criteria:

• liver cirrhosis

• age between 16 and 75 years

• Patients who have upper GI bleeding symptoms (hematemesis or melena) within 24 hours before enrollment

• Patients whose systolic blood pressure <100 mmHg or pulse rate >100/min at the enrollment

• Patients who were not performed endoscopic or pharmacologic therapy for varices

• Signed informed consent

Exclusion Criteria:

• Pregnancy

• Positive anti-HIV Ab

• A history of severe side-effects or contraindications to study drugs

• Severe cardiovascular diseases: acute myocardial infarction, A-V block, congestive heart failure, ischemic heart disease, hypertension (systolic blood pressure >170 mmHg or diastolic pressure >100 mmHg)

• Chronic renal failure

• Hepatocellular carcinoma with protal vein thrombosis

• Coexisting malignancy except hepatocellular carcinoma