Comparison of Three Different Prophylactic Treatments of Postoperative Nausea and Vomiting (PONV) in Children

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Incidence of postoperative nausea and vomiting (PONV) in children after tonsillectomy with or without adenoidectomy may be as high as 75%.

Several medications may prevent and treat PONV, such as steroids, antidopaminergic drugs and serotonin (5-HT3) antagonists. The objective of this study is to compare three prophylactic antiemetic treatments:

• dexamethasone alone (250 mcg/kg)

• dexamethasone (250 mcg/kg) + droperidol (10 mcg/kg)

• dexamethasone (250 mcg/kg) + ondansetron (150 mcg/kg).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre Hospitalier Universitaire Vaudois
• Treatments: Anesthetics; BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Droperidol; Ondansetron

Criteria

Inclusion Criteria:

• children aged 2-10 y.

• children ASA 1-2

• weight > 15 kg

• tonsillectomy with or without adenoidectomy

Exclusion Criteria:

• intravenous induction

• contraindication to steroids

• contraindication to antidopaminergic drugs

• contraindication to serotoninergic antagonists

• administration of steroids, antidopaminergic drugs, or serotoninergic antagonists in the 24 hours before the surgery

• refusal of parents

• no-french speaking parents