Comparison of Three Opioid Detoxification Treatment Regimens

• Status: Withdrawn
• Trial end date: 2020-10-25
• Target enrollment: 0
• Participant gender: All

Summary

Despite an increased focus on treating opioid use disorder there are relatively few studies that compare the length of time required for detoxification with medications other than buprenorphine. Morphine and tramadol have shorter half-lives than buprenorphine and can be used for opioid detoxification. The proposed protocol aims to address this gap by directly comparing the length of treatment required for detoxification from opioids in a patient-centered manner with oral morphine, tramadol, or buprenorphine-naloxone as well as comparing the severity of withdrawal experienced by patients in each group. The investigators predict that treatment with oral morphine or tramadol will result in a faster completion of detoxification and initiation of naltrexone maintenance.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alabama at Birmingham
• Treatments: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Morphine; Naloxone; Tramadol

Criteria

Inclusion Criteria:

• 18-65 years of age

• Meeting DSM-V criteria for opioid use disorder

• Current use of opiates

• Displaying evidence of opioid withdrawal

• Having no significant current medical/psychiatric illness

• English speaking

Exclusion Criteria:

• Use of methadone or buprenorphine exclusively

• Pregnancy

• Hypotensive

• History of seizures

• Physical dependence on alcohol and/or benzodiazepines that requires treatment