Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma

• Status: Completed
• Trial end date: 2020-01-15
• Target enrollment: 0
• Participant gender: Female

Summary

A randomized clinical trial will be done on 92 patients , randomly divided into two groups by lottery method to compare the efficacy and safety of topical silymarin cream 0.7% with topical 4% hydroquinone cream. Patients will be treated for 3 months and for the next 3 months will be followed up for relapse of melasma.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Islamabad Medical and Dental College
• Treatments: Hydroquinone; Silymarin

Criteria

Inclusion Criteria:

• Female sex.

• Age 18 or older.

• Melasma of different severities, types and patterns

Exclusion Criteria:

• Pregnant or lactating females (Hydroquinone has pregnancy category C and it is not known if it is distributed in breast milk or not).

• Ongoing use of hormonal birth control pills or any hormonal therapy (as they cause hyperpigmentation).

• Use of topical anti melasma therapy within 3 months (efficacy of current therapy cannot be concluded).

• Use of topical steroids within 3 months (as topical steroids will decrease hyperpigmentation).