Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty

• Status: Unknown status
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study, therefore, is to conduct a prospective randomized controlled trial to investigate the blood-conservation effect of TXA in different TKA patients groups with rivaroxaban for VTE prophylaxis, first group by topical application, second group by infusion and a third group of placebo and observe whether there is difference in the occurrence of venous thromboembolism in those patient groups by venographic study

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chang Gung Memorial Hospital
• Treatments: Rivaroxaban; Tranexamic Acid; Tranylcypromine

Criteria

Inclusion Criteria:

• End-stage arthritis of the knee

• Failure of medical treatment or rehabilitation

• Hemoglobin > 10g/dl

• No use of non-steroid anti-inflammatory agent one week before operation

Exclusion Criteria:

• Preoperative Hemoglobin ≦10 g/dl

• History of infection or intraarticular fracture of the affective knee

• Renal function deficiency (GFR < 55 ml/min/1.73m2)which is relative contraindicated for venography

• Elevated liver enzyme, history of liver cirrhosis, impaired liver function and coagulopathy (including long-term use anticoagulant)

• History of deep vein thrombosis, ischemic heart disease or stroke