Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery

• Status: Completed
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

We designed a prospective double-blinded randomized trial in an attempt to detect a difference between tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) in reducing transfusion in patients undergoing cardiac surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Loma Linda University
• Treatments: Aminocaproic Acid; Tranexamic Acid

Criteria

Inclusion Criteria:

1. Is the subject 18 years of age or older?

2. Is the subject scheduled for primary cardiac surgery utilizing cardiopulmonary bypass(CPB)?

3. Is the subject more than 30 kg ( 66 lbs)?

4. Does subject understand English?

Exclusion Criteria:

1. Does the subject have existing coagulation defects (INR > 1.5, platelets < 100 ?

2. Does the subject have renal failure (defined as BUN/Cr ratio 20:1 ?

3. Does the subject have severe liver disease (AST & ALT> 3x normal) ?

4. Is the subject having emergency cardiac surgery, complex aortic surgery, combination valve/CABG surgeries, or redo cardiac surgery?

5. Is the subject having any procedure where CPB is not anticipated?

6. Is the patient weight greater than 150 kg?