Comparison of Treatment by IM Ketamine to IV Ketamine in Patients With Renal Colic
Status:
Unknown status
Trial end date:
2021-08-01
Target enrollment:
Participant gender:
Summary
Patients who present to the emergency department (ED), with acute pain due to renal colic,
are often treated with opioids. Treatment with opioids has many disadvantages -
cardio-respiratory depression, nausea, vomiting and long term dependence. For these reasons,
there is a constant search for a way to reduce the use of opioids. ketamine has been proven
to augmented the analgesic effect of opioids, and thus reduce the use and adverse effects of
opioids. Different studies about the use of Ketamine as a sedition agent have shown that
Ketamine given IM versus IV has longer duration of effect with less adverse effects.
The study we are conducting is designed to test and analyze the safety and efficacy of IV
Ketamine with IV Morphine compared to IV Ketamine and morphine with IM placebo in a setting
of acute pain due to, or suspected renal colic in the ED. When both ways of administration
are given by the protocol as is customary for treatment of pain in the Emergency Medicine
department, and will be a prospective, randomized, double blind, controlled study.