Overview

Comparison of Two Anaesthetics on Brain During Brain Tumour Surgery

Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
0
Participant gender:
All
Summary
Anaesthesia and surgical stress during craniotomy can lead to brain damage and activation of inflammatory response. Consequently inflammatory cytokines (IL6, IL8, IL10) are released. Cell mediated immune balance can increase postoperative complications (infections, wound healing, multiple organ dysfunction). Many studies have shown that volatile anaesthetics reduce systemic and local inflammatory response during major surgery, but animal studies have shown that volatile anaesthetics can induce neuroinflammation (IL6, NF-κB) that leads to decline of cognitive function in rodent and possible human. Our aim was to investigate how anaesthetic technique for craniotomy influences the release of inflammatory cytokines. Our hypothesis was that when optimal neuroprotective strategies are followed during surgery intravenous anaesthesia attenuates inflammatory response comparing to inhalational anaesthesia. The investigators included 40 patients anaesthetised with remifentanil based anaesthesia with sevoflurane (S group) or propofol (P group). Plasma levels of IL6, IL8, IL10 were measured during preoperative, perioperative and postoperative periods of both groups of patients. The investigators also noted emergence parameters, postoperative (pain, shivering, vomiting) and neurological complications after surgery.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University Medical Centre Ljubljana
Treatments:
Anesthetics
Propofol
Sevoflurane
Criteria
Inclusion Criteria:

- age 18-80 years

- American Society of Anaesthesiologists (ASA) physical status I-III

- Scheduled for brain tumour surgery

- Glasgow Coma Score 15

- Cooperative

Exclusion Criteria:

- No written informed consent

- Eendocrine systematic disease

- Ddrugs that alter endocrine metabolism

- History of drug hypersensitivity

- Drug addiction

- Perioperative blood derivatives.