Comparison of Two Application Regimens for Viscosupplementation
Status:
Completed
Trial end date:
2014-04-01
Target enrollment:
Participant gender:
Summary
Viscosupplementation by intra-articular injection of hyaluronate products has recently gained
popularity as a treatment modality of gonarthritis.There is not, however, a consensus on the
best method.Our objective is to evaluate what is the best dosage of viscosupplementation with
hyaluronic acid (OSTEONIL®) associated with 1 ml (20 mg) of triamcinolone hexacetonide. One
hundred and four patients with knee osteoarthritis (KOA) were divides into 2 groups of 52
patients each to receive either a single application of 3 ampoules of OSTEONIL® + 1ml of
Hexacetonide of triamcinolone or three applications of 1 ampoule of OSTEONIL®, one per week
for three weeks + 1ml of Hexacetonide of triamcinolone only in the first injection. Primary
endpoint was clinical results expressed by Visual Analogic Scale of pain (VAS), Western
Ontario and Mcmaster Universities (WOMAC) and Lequesne questionaires at one, three, six and
12 months after the procedure