Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess

• Status: Completed
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Aim: The aim of this study was to compare the analgesic efficacy of two combinations of opioid and non-opioid analgesics for acute periradicular abscesses.

Methodology: This study included 24 patients who sought emergency care in a Brazilian dental school. The patients were randomly divided into two groups: Codeine/Acetaminophen - oral prescription of codeine (30 mg) plus acetaminophen (500 mg), every 4 h, for 3 days or Tramadol/Acetaminophen - oral prescription of tramadol hydrochloride (37.5 mg) plus acetaminophen (500 mg) on the same schedule. Patients recorded pain scores in a pain diary 6, 12, 24, 48, and 72 h after treatment, using the Visual Analogue Scale.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federal University of Rio Grande do Sul
• Collaborator: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
• Treatments: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Tramadol

Criteria

Inclusion Criteria:

• Clinical diagnosis of Acute Periradicular Abscess

• Age greater than 18 years

• Spontaneous pain greater than 40 mm measured in Visual Analogue Scale (moderate to severe pain).

Exclusion Criteria:

• Intake of analgesics or antibiotics within 4 hours prior to emergency surgery

• Allergy to the drugs used in this study

• Gastric ulcer, liver or kidney disease

• Uncontrolled diabetes mellitus or epilepsy

• Pregnancy or lactation