Comparison of Two Different Natural Surfactants in the Treatment of Pulmonary Hemorrhage
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
The incidence of pulmonary hemorrhage (PH) was about 1.3 per 1,000 live births. PH occurs
mainly in preterm ventilated infants with severe respiratory distress syndrome (RDS) who
often have a PDA and have received surfactant. Although not clear, the cause of PH is thought
to be due to a rapid lowering of intrapulmonary pressure, which facilitates left to right
shunting across a patent ductus arteriosus and an increase in pulmonary blood flow.
Prospective uncontrolled studies that used surfactant for PH in neonates have shown promising
results in treating PH.In this study we aimed to evaluate the effect of two different natural
surfactants in neonates with pulmonary hemorrhage.