Comparison of Two Dose Regimens of Snake Antivenom for the Treatment of Snake Bites Envenoming in Nepal

• Status: Completed
• Trial end date: 2013-03-20
• Target enrollment: 0
• Participant gender: All

Summary

This study aims at comparing two doses of antivenom in the treatment of snake bite envenoming. It will take place in 3 centers in rural Nepal and will involve 250 snake bite victims presenting with one or more sign of neurotoxic envenoming. The objective of the study is to generate enough scientific evidence to improve Nepal's current national guidelines for the management of snake bites.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: CTU
• Treatments: Antivenins

Criteria

Inclusion Criteria:

• History of snake bite; AND

• Age ≥ 5 years; AND

• Informed consent obtained; AND

• Showing one or more signs of neurotoxic envenoming

Exclusion Criteria:

• Subject unlikely to co-operate in the study

• Pregnant or breastfeeding women

• Patients presenting more than 24 hours after the bite

• Patients requiring ventilation support at the time of presentation

• Subjects with previous history of snake bite with envenoming

• Patients who already received antivenom before presenting to the study centre

• Patients with pre-existing neurological or muscular disorders

• Subjects with known history of allergy to horse proteins

• Patients with proven viper bites