Comparison of Two Doses of Intranasal Dexmedetomidine as Premedication in Children

• Status: Completed
• Trial end date: 2010-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Intranasal dexmedetomidine has shown to be an effective sedative when used prior to anaesthetic induction as premedication. 1mcg/kg intranasal dexmedetomidine was used in previous study and it produced satisfactory sedation in more than 50% of the children at the time of anaesthetic induction with no adverse effect. In this study we aim to compare 1mcg/kg with 2mcg/kg intranasal dexmedetomidine in children. We expect more children would attain satisfactory sedation prior to anaesthetic induction when higher dose is used.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Hong Kong
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• Age 1-12 years old

• American Society of Anesthesiologists (ASA) 1-2

• Elective surgery

• Children with autism or pervasive personality disorder

Exclusion Criteria:

• American Society of Anaesthesiologists (ASA) 3-5

• Allergy or hypersensitive reaction to dexmedetomidine

• Known cardiac arrhythmia or congenital heart disease

• Mentally disabled