Comparison of Two Drugs Regimen in Treatment of Complicated Typhoid Fever in Children

• Status: Completed
• Trial end date: 2020-12-30
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates whether XDR Typhoid fever in children can be effectively treated with monotherapy (meropenum alone), or a combination (meropenum and azithromycin).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ziauddin University
• Treatments: Azithromycin; Meropenem

Criteria

Inclusion Criteria:

Patients with extended drug resistant typhoid fever defined as culture proven typhoid fever caused by Salmonella Typhi or Para typhi resistant to Ampicillin, Chloramphenicol,Co trimoxazole,Quinolones and Ceftriaxone along with two or more of the following condition

• High grade fever spikes for more than three days

• Refusal to eat or drink

• Drowsy or Unconscious

• Convulsions

• Dehydration due to diarrhea or vomiting

• Abdominal distension with or without tenderness

• Bleeding diathesis like petechial rash, gum bleed, melena

• Jaundice or alanine transaminase more than twice of the normal range

• Thrombocytopenia less than fifty thousand

• Increase Prothrombin time and activated partial thromboplastin time

• Electrolyte imbalance like hyponatremia, hypernatremia, hypokalemia, hyperkalemia, metabolic acidosis

• Hypoglycemia

• Signs of shock like cold and mottled skin, feeble pulses, tachycardia, decreased blood pressure

Exclusion Criteria:

• Not given informed consent

• Children who need ventilator or two inotrope support

• Severe malnutrition/immunocompromised patient