Comparison of Two Intravenous Lipid Emulsions in Home Parenteral Nutrition Patients
Status:
Completed
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
Total Parenteral Nutrition (TPN) is a way of feeding a person intravenously, and is required
when the gastrointestinal tract is not able to function properly. TPN contains carbohydrates,
protein, and fat and lipids. It also contains minerals and vitamins. The lipid that is
currently used at the University Health Network home TPN program is Intralipid20%, which is
based on Soybean oil, contains polyunsaturated fats and is a good source of energy and
essential fatty acids, including omega 3 and 6 fatty acids, which needed by the body.
However, long term use on Intralipid20% has been shown to have negative effects on
antioxidant status, inflammation, liver, and the immune system.
SMOFlipid20% is a lipid emulsion that has been designed to maximize the ratio of omega 3 to
omega 6 fatty acids, in an effort to avoid potentially harmful effects associated with
Intralipid20%. In previous studies, it has been shown that SMOFlipid20% is safe and has
positive benefits on the liver enzymes. There are no studies so far which follow patient who
is on SMOFlipid20% long term. The investigators hope to show that with long term use of
SMOFlipid20% is better for liver function compared to Intralipid20%.