Comparison of Two Regimens of Dexamethasone in the Prevention of Hypersensitivity Reactions to Paclitaxel, a Pilot Study
Status:
Completed
Trial end date:
2013-08-01
Target enrollment:
Participant gender:
Summary
This is a prospective, randomized, unicentric, two-arm, parallel, controlled, and double
blind pilot study.
The purpose of this pilot study is to assess the feasibility of a trial designed to compare
the quality of life of patients taking dexamethasone in two different ways to prevent
hypersensitivity reactions to paclitaxel.
Dexamethasone given intravenously (IV) 30 minutes before paclitaxel could improve quality of
life, could adequately prevent hypersensitivity reactions to paclitaxel and could reduce
adverse effects compared to dexamethasone given orally 12 hours and 6 hours before
paclitaxel.